Insights into the structure-function relations of amorpha-4,11-diene synthase
نویسندگان
چکیده
منابع مشابه
Isolation, characterization and structural features of amorpha - 4, 11-diene synthase (ADS3963) from Artemisia annu L
With the escalating prevalence of malaria in recent years, artemisinin demand has placed considerable stress on its production worldwide. At present, the relative low-yield of artemisinin (0.01-1.1 %) in the source plant (Artemisia annua L. plant) has imposed a serious limitation in commercializing the drug. Amorpha-4, 11-diene synthase (ADS) has been reported a key enzyme in enhancing the arte...
متن کاملThe presence of amorpha-4, 11-diene synthase, a key enzyme in artemisinin production in ten Artemisia species
BACKGROUND AND THE PURPOSE OF THE STUDY Artemisinin is one of the most effective medicine against malaria, which is produced naturally by Artemisia annua in low yield. It is produced in a metabolic pathway, in which several genes and gene products are involved. One of the key genes in this pathway is am1, which encodes amorpha-4, 11-diene synthase (ADS), a key enzyme in artemisinin biosynthesis...
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ژورنال
عنوان ژورنال: Biotarget
سال: 2018
ISSN: 2522-669X
DOI: 10.21037/biotarget.2017.12.02